[sticky entry] Sticky: Modsock Post

Apr. 25th, 2013 05:07 pm
x_essex: (Default)
This journal belongs to the X-Project RPG. This character has been retired from active play and is now a modsock. The journal is kept for continuity purposes.

X-Project is an X-Men movieverse RPG on Livejournal. Set after X2, we've been running since May 2003 and use a combination of in-character journals and email/IM logs. There's a number of settings for a range of play, whatever your preference, and while we accept new characters we strongly encourage people to adopt one of our orphans.

Check out the Wiki and the advertising community to see what's available. Readers are highly encouraged! If you're looking for X-Men based entertainment, X-Project welcomes you to read along and enjoy the ride!

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x_essex: (Default)
This journal belongs to the X-Project RPG. This character has been retired from active play and is now a modsock. The journal is kept for continuity purposes.

X-Project is an X-Men movieverse RPG on Livejournal. Set after X2, we've been running since May 2003 and use a combination of in-character journals and email/IM logs. There's a number of settings for a range of play, whatever your preference, and while we accept new characters we strongly encourage people to adopt one of our orphans.

Check out the Wiki and the advertising community to see what's available. Readers are highly encouraged! If you're looking for X-Men based entertainment, X-Project welcomes you to read along and enjoy the ride!

Rules | Application | Available Characters | Game Wiki | Read The Game | FAQ|Contact Us | Follow Us on Twitter!


Sep. 23rd, 2003 09:15 am
x_essex: (pic#)
Ladies and gentlemen,

I am taking a daytrip to Seattle tomorrow on business. Those of you who have appointments with me will have to reschedule. Those of you who wish to join me will have to inform me of that. I will be taking an earlier flight and leaving on a red-eye back to the school, so I can't imagine you'd have more than seven or eight hours of sightseeing. However, the offer is open.
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Scotland. It's much like hell, only with thicker accents and less teeth.

Ten feverously long days at Muir Island, looking at one of the world's premiere mutant research organizations being reduced to garbage. Doctor MacTaggert, it's unacceptable and without precedent. Thanks to efforts on both the Blair and Bush administrations, several different types of research tools used predominantly in mutagenic and genetic experimentation have found their way on to the 'controled list', meaning that only an accredited government research facility is allowed access to them. Obviously, Doctor MacTaggert was growing mutant terrorists to threaten NATO or some such nonsense. It would appear that most of our samples and research has been saved, yet still stopped, unable to be restarted without the proper equipment. While the mansion holds a great deal of said (now highly illegal, Charles) equipment, it cannot hold the research facilities and numbers required.

For the uninitiated, allow me to explain what this means. Until such time as we can either reverse the ruling, or grant government oversight into Muir Island, our most vital research is in most ways defunct. Imagine trying to perform an autopsy with a plastic knife, and you approach the limitations this places on us.

Really, when you think of it, what these 'leaders' are doing is ceding the initiative to research labs in the Middle East, Asia and South America. Perhaps I'm confused, but where those not countries that produced the terrorists so feared by those same politicians?

Moria, I will be in touch next month. I will try and arrange some kind of liasion work. Perhaps by taking on some contractor style work, we can regain access to some of the equipment. Otherwise, we're looking at extensive partnerships on the Pacific Rim and the Middle East. I assume that the conference in Kuwait is suddenly high priority. The Mandarin Bio-Technology Ring has heavily invested in the US through Stark Industries, which means we might be able to bring them into the fold. Perhaps Professor Farouk might have some contacts through the universities that we might pillage.

That was my unanticipated vacation. I do hope my lab is not overrun with cobwebs, ramen wrappers, and whatever that violently green soda that Ms Pryde seems to favour. I shall be detained for much of the next few weeks, taking a much larger workload of the more time crucial experiments from Muir in hand. If there is anything you require of me, I highly recommend you inform me with all alacrity.

--Dr N. Essex
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SARAH MORLOCKE - FILE#072303-0008 [22:57:04]

Subject shows extremely rapid and uncontrolled ossification of skeletal frame. The body produces 'flares' and 'flanges' of dense spun bone material, which is extruded from existing bones and pushed through the flesh to be discarded. Samples show much higher levels of calcium phosphorous and trace minerals evident in extruded samples than normally found in the human body.

Investigation of chondrocyte metabolism, which forms part of the complex spatial organization of the growth plate, is essential for identifying and manipulating the pathways of normal and abnormal development of bone. The effects of chemical signals, cytokines, systemic hormones and growth factors on cell proliferation and differentiation were studied. Tools such as cell lines stably expressing hormone receptors have been developed. Chondrocytes in situ may deviate from their original state of differentiation therefore a set of markers of differentiation, including cell morphology, specific matrix protein synthesis and enzyme activities has been defined. Specific mutations in growth factor receptors which cause abnormal chondrocyte differentiation have been evaluated. In addition, involvement of various hormones and their receptors in the aetiology of the mutation have been studied. All of these studies intended to elucidate the normal growth plate development.

Calcification of bone is a complex process in which a calcium-phosphate mineral phase is deposited in a highly ordered fashion within the organic matrix. Apart from the availability of calcium and phosphorus, requirements for normal mineralization include: 1) adequate metabolic and transport function of chondrocytes and osteoblasts to regulate the concentration of calcium phosphorus and other ions at the calcification sites; 2) the presence of collagen with unique type, number and distribution of cross-links, distinct patterns of hydroxylation and glycosylation and abundant phosphate content, which collective facilitate deposition of mineral at gaps (or "hole zones") between the distal ends of collagen molecules; 3) a low concentration of mineralization inhibitors (such as pyrophosphates and proteoglycans) in bone matrix; and 4) maintenance of an appropriate pH of approximately 7.6 for deposition of calcium-phosphorus complexes.

The abnormal mineralization in the hypophosphatemic disorders, is due most likely to phosphopenia at calcification sites and, in some cases, paracrine inhibitory factors, which result in accumulation of unmineralized osteoid, a sine qua non for the diagnosis of osteomalacia. Since the resultant abundant osteoid is not unique, however, establishing the diagnosis of osteomalacia histopathologically requires demonstration that abnormal mineralization, and not increased production, underlies the pathological abnormality. Concordance of these events is manifest by an increase in the bone forming surface covered by incompletely mineralized osteoid, an increase in osteoid volume and thickness and a decrease in the mineralization front (the percentage of osteoid-covered bone-forming surface undergoing calcification) or the mineral apposition rate.

The inadequate cartilage mineralization in rickets is confined to the maturation zone of cartilage wherein the height of the cell columns is increased and the cells are closely packed and irregularly aligned. Moreover, calcification in the interstitial regions of this hypertrophic zone is defective. These changes result in increased thickness of the epiphyseal plate, accompanied by an increase in transverse diameter that often extends beyond the ends of the bone and causes characteristic cupping or flaring. Longitudinal bone growth, which determines the size and shape of the body frame, proceeds at a rate distinct from those of muscle and other tissues and is controlled by specific mechanisms. The epiphyseal growth plate of the long bones is of utmost importance in the process of bone elongation and growth. From the practical viewpoint, irregular metabolism in the growth plate area is associated with dwarfism and tibial dyschondroplasia. The traditional approach has not so far resulted in feasible protocols to reduce the occurrence of abnormal bone growth substantially.

Given the random nature of the extruded growths, it is noted that the subject has not yet suffered anything greater than superficial injury from her growths. Considering that the bones do not follow any specific pattern, a rudimentary or unconscious control of the growth must be existent to prevent such an incidence. Subject also shows no kidney or liver damage, which would be consistent with the advanced ossification and reabsorption of the calcium phosphates. This indicates that all mineral absorption returns to the development of new bones. Subject also displays a rapid or quantum healing rate, which prevents permanent tissue and nerve damage from bone extraction.


CHEMICAL INHIBITERS OF OSSIFICATION: Using a combination of drugs, we can inhibit the growth of bones tissue by a factor of two or three. Leeching out the needed mineral components and directly interfering with the growth triggers in the subject's system. The disadvantages are that there is no telling what reaction the X factor would have on the system, with a danger of internal damage.

BONE SHEATHING: By artificially sheathing the skeletal frame with nanite bundles, we can absorb the excess minerals and retard all bone growth beyond a programmed limit. Nano-bundles would be converters, changing over minerals into bio-energy needed to sustain limits. Of course, this would require extensive surgery to implant control centres on the skeletal frame, and would eliminate the possibility of the subject ever using mutation on any level.


LIMITED NANO-GROWTH INHIBITERS: We can implant a control chip in the spinal column that will serve as an internal monitor of the skeletal integrity. Using the data, we can selectively choose which growths to encourage to grow by placing bioterminal nanopackets into the area and terminating growths in unwanted areas. The resulting increased material would allow for faster and more directed ossification, leading to shorter withdrawal times. The packets would be absorbed into the body and broken down as their limited power expires. The treatment offers no real negatives, save for time requirements that would be inherent in monitoring and packet injection.
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I have spent the most marvelous week, locked in my basement lab and puzzling over the nature of the universe as seen through the genetic material of several mutants. The concept of generation occurred to me in direct relation to the work I'm progressing. The idea of an evolutionary process follows two paths; that of slow trait reinforcement and of cataclysmic change. However, with new regenerative technologies being developed, the natural changes are being artificial stimulated, which means that you are going to have divergent generational paths based along a technological scale from now on. Fascinating.

Memo: There is some interesting work being due on the West Coast by Krensler and Ross at Berkley on this. Contact CO for additional information.
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"Golf. The best way to ruin a good walk."

I think Sir Winston might have had something there. After an appalling outing at Ardsley, I think I may have to avoid the annual game with the Capitol AMA's this year. Much of my field's professional standing is linked heavily to golf, no doubt to the chagrin of the person being operated on by a third rate neurosurgeon but a first rate short gamesman. As long as he replaces the divots, I assume.

So many attacks of conscience in the last few days. A Clinton tell-all book, a celebrity indictment, and a retiring general over an unfortunate brunch. Really, so much to learn about in the world, and so few really looking at things.

My former associates have let slip that the final links to Stryker's failed program have been purged from the system. No doubt the oversight committee will continue to hound the Pentagon on the details, but for naught. I wonder if anyone has considered following the shift of research personnel? There are a limited number of truly skilled researchers in the field, and even fewer under military contract.

Memo: Contact Colonel Abraham B. Cornelius about old friends. Let's see who's got a brand new bag, so to speak.

I received a letter by IOMS yesterday, asking me to consider a symposium in Kuwait early next year on cloning. The IOMS convened a seminar in 1983 on "Reproduction in Islam", in which two papers were presented dealing with the possibility of human cloning as a result of successful cloning in plants, frogs and small marine animals. The Seminar made the following recommendation: "To exercise prudence in giving a Shari'ah- based opinion on human cloning (as achieved in animals) and to call for further medical and Islamic investigation of these issues. It would be possible to apply genetic engineering of micro-organisms using the recombinant DNA technology to produce medicinal substances in abundant supply ." I'm afraid the topic hasn't developed much in examination since.

Islam has a very real interest in cloning from an agricultural prospective. The arid lands of the Middle East, save for fertile bands around the four great rivers, could benefit greatly from genetically modified food plants and cloning to augment their breeding stocks. Islamic communities in Asia face similar pressures, especially given the nature of the Pan-Pacific belt. However, the often contradictory strictures of the Quran have created a wide rift in their scientific community on whether it is right to do so, and if so, under what conditions?

I hear that Kuwait lacks golf courses. I should consider this.
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Our initial results look good. While we have found fraying along the upper registers, the overall matrix seems to be stable, which is the most important thing.

Memo: Contract General T. Ross about New Mexico facility. See if we can arrange some time with Banner's team on HSP90 mapping.

I had forgot ton what a unique environment the school system creates. I've been out of teaching for a number of years now, and the private research environment is very different. For one thing, I have yet to have a small child disassemble my pocket watch in a major lab.

Still, there are some advantages, mostly in the aspect of pressure. Charles' research facilities do have some limitations (and an apparent fierce competition for space), but are adequate for my specific needs. Save the odd incorporeal visit, it could be any lab in North America. However, it is hardly the research advantages that concern me.

It's the children. Normally, this would include some sort of impassioned plea for speedbumps or frontal lobotomies by parent groups. I am of less compassionate humour. No, it is the diverse mixture of mutation, so readily available and integrated. I wonder when the first crisis point will hit, say a power damper affecting a student in the midst of a transition, causing injury.

Documenting the staff and students have been slow, mostly due to my own research requirements, and also due to my winning personality. It would seem that I cut across the established grain of ethos in this school. Personally, I couldn't be more delighted, but it has limited the invitations for crumb cake and cappuccino. I'm so loathe to schedule actual consultations, but that might be needed.

Or, I could keep opinion muted.

Schedule it may be.

I wonder if there are any golf courses nearby. I do so love living up to stereotypes. Besides, it might be nice to get out into the open for a few hours. I missed the trip to the amusement park (in much the same way I missed Ebola: careful pre-planning and protective measures), but find myself somewhat unaware of the charms of Westchester. Tell me there is a meal to be had that is not served out of a clown's mouth in a paper sack.


May. 30th, 2003 04:24 pm
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Capital. Reminds me of Oxford, without the acid, lager and Sex Pistols playing in the background, that is.

The tensions of an army draw close even this soon, with some very martial releases being explored. Ah Charles, you wanted a school and founded an army instead. There is irony in that, don't you think? Mutant High with its very first ROTC program.

Where will the decisions go, I wonder? Demerits, loss of priviliages, nights in the Box between beatings with a rubber hose? So many possibilities. Still, in a world of telepaths, it would be intriguing to see a mind to mind solution: taste the pain of your victim.

Such is life. Still, this weekend should be a productive one in the lab. We are almost ready for an inital test.
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I have worries that my lecture might be postponed due to injury. On the part of my students, that is. I seem to recall a Marine doctor from Silver Springs who was working on rehabilitive surgical techniques talking about his old drill sergeant. He said the reason he went into that medical field was to find a way to finally heal after eight weeks of Basic.

Lecturing. One of the advantages of research is the fact that there are no students. There are barely other researchers. Most groundbreaking work is done within the scientific community, but still generated by the sole project conceptualizer. Not to discredit the bottle washers and swab cleaners, but their is rarely more than one true mind on a program.

There is a sudden influx in new students, it appears. One nearly made it down to the lab without psychic coercion. I suppose I should resign myself to visitors while I work. One always is nervous that some powers can conflict with readings, but I can devise methods around such. Dr.McCoy's bio-ethics conference gives me the luxury of not sharing lab space, which means that I can action my new analysis program in that time.

Bio-ethics. We have found the flipside of eugenics, and it is equally ridiculous. Medical ethos have existed in Western medicine for thousands of years, stemming back to the base idea of 'First, Do No Harm'. Noceology should be the current study. The morality or immorality of genetic experimentation is a valueless argument, as man has been involved in that since the dawn of time. Every step in medical knowledge has tampered with the nature of human development.

What should be the issue is the definition of harm. What constitutes harm? Is failing to research the screening of genetic information in the womb and developing therapy to treat disorders 'harming' potential humans and mutants? Quibbling about whether or not to allow genetically modified carrots into stores and where we can glean stem-cells from is the make-work of lesser minds, casting chains of administration over those who labour towards real knowledge.

The lesson is a central principle of science; identify the true question first, the very thing that must be explained, and all knowledge will follow from that.


May. 22nd, 2003 12:04 am
x_essex: (Default)
I can, theoretically, be reached via sinisterdna on AIM. That is all
x_essex: (Default)
As a rule, I hate airports. Not that superficial, 'I'm tied up in a line with a squalling infant' sort of bothersome irritation, but true, deeply ingrained hatred of the entire system of entering and exiting a plane. If this was so even before the underworld decided to start crashing planes into national monuments, you can imagine what I feel now, in the absolute stranglehold of security which one now must face.

When you spend as much time as I do in such places, you begin to recognize the finer edges to that specific reality. You can almost taste the emotions seeped into the cheap floor tiling and taupe walls. Airports are all about desperation and loss.

The missed connection, the security strip search, the separation from family. Each person has smothered their expectation in a myriad mixture of sorrow, guilt, fear and abandonment. Each child who enters is made a temporary orphan, each wife a widow. The pilots hide studious prayers that things will not go wrong behind several hundred pre-flight procedures, a delusional sacrifice which is ritualistically (if not hygienically) little better than divining about the insides of a chicken.

Ever since I've known him, Charles has always flown in private charters. Does his mind feel that knife of emotion more keenly here, I wonder? Does the PSIon receive not just the emissions of active minds, but also the residual echoes from those gone before? Memo to myself: e-mail Professor Yamagori and Professor Richards on possibility.

So, I am taking the train up to Westchester. There is an inferior red and a quite surprising Chicken en Papillote in my future, according to the brochure. I once heard a rumour that they serve food on the plane. I have yet to see proof of that. I really must secure a vehicle once I arrive. If you find the atmosphere of an airport unspeakably despondent, you can only imagine the horrors that travel with a taxi.


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Dr. Nathaniel Essex

April 2013

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